Beilstein J. Nanotechnol.2020,11, 263–284, doi:10.3762/bjnano.11.20
nanoparticles; plasmonics; single-pointmutation; Introduction
Cancer is a leading cause of death accounting for about 8.8 million deaths in 2015 [1]. The list of tumor-linked substances, i.e., biomarkers for diagnosis and prognosis purposes is continuously increasing. Cancer biomarkers are present in tumor
by discussing current technologies in clinics, we review the performance of recent sensors for single-pointmutation in which gold nanoparticles act as signal transducers. We classify the discussed sensors according to whether the underlying mechanisms of detection involve enzymatic reactions or not
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Maeda et al. have proposed the so-called noncross-linking method for SNP detection, which is based on the nonselective aggregation of one single type of DNA-coated gold nanoparticles (Figure 3b) [62]. The target DNA (15 bases) containes a single-pointmutation at the 5′ terminus, which provides steric
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Figure 1:
Alterations in cell-free DNA. Cell-free DNA can be released from both cancerous and normal cells lo...